Strategic Prevention Framework - Partnerships for Success for States

The Strategic Prevention Framework - Partnerships for Success (SPF-PFS) for States is a forecasted grant opportunity issued by the Substance Abuse and Mental Health Services Administration (SAMHSA), part of the U.S. Department of Health and Human Services. This funding initiative is part of a broader effort by SAMHSA to mitigate the negative consequences of substance use and reduce the prevalence of substance use disorders across the United States. Through the SPF-PFS program, SAMHSA seeks to enhance the ability of states, U.S. territories, Pacific jurisdictions, and the District of Columbia to implement prevention strategies that are community-based, evidence-informed, and culturally appropriate. The purpose of the SPF-PFS States program is to prevent and reduce the initiation and progression of substance use and its related harms. It aims to accomplish this by funding states to develop and deliver prevention services that emphasize strengthening protective factors, reducing risk factors, and building resilience at the community level. Emphasis is placed on the expansion of prevention service capacity, particularly among providers serving underserved and tribal communities. Funded projects are expected to adopt prevention strategies that are either evidence-based, informed by research, or community-defined and proven to be effective. Funding for this grant is estimated at $8.2 million, with approximately four awards expected to be made. While the opportunity does not require cost sharing or matching funds, applicants must demonstrate their capacity to implement comprehensive prevention services. Specific funding amounts, ceilings, and floors have not yet been disclosed and will be clarified upon full NOFO release. The assistance listing number associated with this opportunity is 93.492, which corresponds to the Center for Substance Abuse Prevention Projects of Regional and National Significance. Eligibility is limited to states, including U.S. territories and Pacific jurisdictions, as well as the District of Columbia. This restriction highlights SAMHSA’s intention to operate at the macro-policy and systems level, leveraging statewide structures to ensure prevention initiatives have broad and sustainable impact. Local governments, nonprofits, and other entities are not directly eligible under this forecasted opportunity but may become involved through partnerships with eligible lead applicants. The grant opportunity is currently in a forecasted stage, with an estimated post date of May 1, 2026. The application due date, award date, and project start date are not yet specified. No pre-application requirements or gating documents have been noted, and submission is expected to be routed through Grants.gov, following standard federal protocols. As a forecasted opportunity, it is anticipated to recur on an annual or similar basis, although recurrence language is not explicitly stated in the source material. Interested applicants are encouraged to monitor the opportunity on Grants.gov and prepare by reviewing existing SPF-PFS state-level implementation models, ensuring readiness to address expected evaluation and reporting standards. For further information, inquiries can be directed to Damaris Richardson at 202-924-0334 or via email at [email protected]. Additional updates and the official application package are expected to be released closer to the estimated post date.