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Grants for Nonprofits - Federal

Explore 5,534 grant opportunities

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed)
$250,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Oct 14, 2026

Date Added

Oct 16, 2024

Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed) aims to support the clinical validation of already analytically validated biomarkers and assays for cancer detection, diagnosis, and treatment monitoring, ensuring they are reliable and ready for use in clinical studies without conducting new trials.

Education
State governments
FY 2026 Sports Diplomacy On Demand Program
$2,000,000
U.S. Department of State (Bureau Of Educational and Cultural Affairs)
Federal

Application Deadline

May 26, 2026

Date Added

Mar 27, 2026

This funding opportunity supports U.S.-based nonprofits or educational institutions in implementing short-term, sports-focused international exchange projects that promote cross-cultural understanding and align with U.S. foreign policy priorities.

International Development
Nonprofits
Water and Waste Facility Loans and Grants to Alleviate Health Risks for Colonias
Contact for amount
U.S. Department of Agriculture (Rural Development)
Federal
Rolling

Application Deadline

Not specified

Date Added

Jun 27, 2025

This program provides financial assistance to rural communities along the U.S.-Mexico border to improve access to safe drinking water and waste disposal services, addressing serious health risks in historically underserved areas.

Infrastructure
State governments
National Centers for Cryo-electron Tomography (cryoET) (R24 -Clinical Trial Not Allowed)
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jan 26, 2027

Date Added

Jun 10, 2025

This funding opportunity supports the establishment of national service centers that provide researchers with access to advanced cryo-electron tomography technologies, along with training and assistance in sample preparation and data analysis.

Health
State governments
FY 2024 2026 Broad Agency Announcement (BAA), National Marine Fisheries Service
Contact for amount
U.S. Department of Commerce (DOC NOAA - ERA Production)
Federal

Application Deadline

Sep 30, 2026

Date Added

Jul 30, 2024

This funding opportunity supports innovative projects and research aimed at sustainable fisheries management, protected species recovery, and marine ecosystem enhancement, targeting a wide range of applicants including educational institutions, nonprofits, and government entities.

Environment
State governments
Information Innovation Office (I2O) Office-Wide
Contact for amount
U.S. Department of Defense (DARPA - Information Innovation Office)
Federal

Application Deadline

Nov 30, 2026

Date Added

Dec 1, 2025

This funding opportunity invites innovative research proposals from a wide range of organizations, including universities and small businesses, to develop groundbreaking technologies in information and computational science that enhance national security.

Science and Technology
For profit organizations other than small businesses
Safety, Security, and Privacy of Open-Source Ecosystems
$1,500,000
National Science Foundation
Federal

Application Deadline

Apr 28, 2026

Date Added

Jun 2, 2025

This funding opportunity is designed to enhance the safety, security, and privacy of established open-source software communities in the U.S. by addressing critical vulnerabilities and supporting innovative solutions.

Science and Technology
City or township governments
Countering Cartel Recruitment in Mexico
$1,500,000
U.S. Department of State (Bureau of International Narcotics-Law Enforcement)
Federal

Application Deadline

Apr 6, 2026

Date Added

Feb 9, 2026

This funding opportunity provides financial support to non-profit organizations and educational institutions working to disrupt cartel recruitment in vulnerable youth across six high-risk states in Mexico, enhancing regional stability and reducing cross-border threats.

Law Justice and Legal Services
Nonprofits
Freedom 250: Kazakhstan Youth Leadership Camp
$80,000
U.S. Department of State (U.S. Mission to Kazakhstan)
Federal

Application Deadline

Apr 17, 2026

Date Added

Mar 13, 2026

This grant provides funding for organizations to host a youth leadership camp in Kazakhstan, aimed at empowering FLEX program alternates through workshops on entrepreneurship, financial literacy, and leadership development.

Youth
Nonprofits
Community Reentry Settings Initiative
$100,000
U.S. Department of Justice (National Institute of Corrections)
Federal

Application Deadline

May 4, 2026

Date Added

Mar 6, 2026

This funding opportunity is designed for organizations with extensive experience in criminal justice research to evaluate and improve the decision-making processes used by state Departments of Corrections for placing individuals in community reentry facilities.

Law Justice and Legal Services
Nonprofits
ROSES25: B.6 Heliophysics Technology and Instrument Development for Science
$2,350,000
National Aeronautics and Space Administration (NASA Headquarters)
Federal

Application Deadline

Apr 15, 2026

Date Added

Jan 13, 2026

This grant provides funding for universities and nonprofits to develop innovative technologies and instruments that advance research in solar and space physics, supporting NASA's goals for future space exploration.

Science and Technology
Public and State controlled institutions of higher education
NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed) PAR-25-416
Contact for amount
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 14, 2027

Date Added

May 14, 2025

This funding opportunity supports the development and maintenance of shared biomedical research resources that provide advanced technologies and services to researchers across multiple states or nationally, ensuring broad access for academic investigators.

Science and Technology
State governments
FY 2026 Sports Visitor Program
$4,000,000
U.S. Department of State (Bureau Of Educational and Cultural Affairs)
Federal

Application Deadline

May 26, 2026

Date Added

Mar 27, 2026

This grant provides funding for U.S. nonprofit organizations to implement an international sports exchange program that fosters youth development, leadership, and cultural understanding through sports activities for young people and their coaches from the U.S. and abroad.

International Development
Nonprofits
Animal and Biological Material Resource Centers (P40 Clinical Trial Not Allowed)
$650,000
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Sep 26, 2028

Date Added

Jun 10, 2025

This funding opportunity provides support for specialized research centers that develop and maintain laboratory animal colonies and biological materials, promoting scientific rigor and accessibility for researchers across the U.S. biomedical community.

Health
State governments
Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)
$4,000,000
U.S. Department of Health & Human Services (National Institutes of Health)
Federal

Application Deadline

Jul 17, 2026

Date Added

Dec 6, 2024

This funding opportunity supports researchers in utilizing existing datasets to advance the understanding of substance use behaviors and related health issues, particularly focusing on critical health disparities and innovative analytical approaches.

Health
Public and State controlled institutions of higher education
State and Jurisdictional Humanities CouncilsGeneral Operating Support Grants
$1,700,000
National Endowment for the Arts (National Endowment for the Humanities)
Federal

Application Deadline

Apr 6, 2026

Date Added

Mar 4, 2026

This funding opportunity provides financial support to state and jurisdictional humanities councils to enhance their operations and promote humanities education and public awareness in local communities across the United States.

Humanities
Nonprofits
NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)
Contact for amount
U.S. Department of Health and Human Services (National Institutes of Health)
Federal

Application Deadline

Jun 6, 2026

Date Added

Mar 4, 2026

This funding opportunity supports multi-center clinical trials aimed at improving treatments for neurological emergencies, such as traumatic brain injuries and status epilepticus, by utilizing a specialized research network.

Health
State governments
BJA FY25 Residential Substance Abuse Treatment (RSAT) for State Prisoners Training and Technical Assistance Program
$700,000
U.S. Department of Justice (Bureau of Justice Assistance)
Federal

Application Deadline

May 4, 2026

Date Added

Mar 27, 2026

This funding opportunity provides support to organizations that assist state and local correctional facilities in implementing effective substance use treatment and aftercare programs for incarcerated individuals.

Health
Public and State controlled institutions of higher education
Make America Healthy Again - Enhancing Lifestyle and Evaluating Value-based Approaches Through Evidence
$3,300,000
U.S. Department of Health and Human Services (Center for Medicare and Medicaid Services)
Federal

Application Deadline

May 15, 2026

Date Added

Mar 16, 2026

This funding opportunity supports a variety of organizations in implementing and evaluating innovative lifestyle medicine interventions to improve health outcomes and reduce costs for Medicare beneficiaries.

Health
Nonprofits
Probability
Contact for amount
National Science Foundation
Federal

Application Deadline

Sep 15, 2026

Date Added

Oct 4, 2024

This funding opportunity supports researchers in probability theory and its applications across various scientific and engineering fields, encouraging innovative projects and interdisciplinary collaboration.

Science and Technology
City or township governments