Grants for Nonprofits - Federal

This grant provides funding to community-based organizations that offer culturally specific services to support survivors of domestic violence, dating violence, sexual assault, and stalking.

This grant provides funding for researchers to develop innovative human cell-based models that mimic the complex structures and functions of the nervous system, particularly focusing on aging and related diseases.

This funding opportunity provides financial support to organizations working in Ukraine to deliver essential HIV prevention, testing, and treatment services, particularly for high-risk populations affected by the ongoing war.

This funding opportunity provides financial support for early-stage researchers in the U.S. to explore innovative studies on HIV-related health issues, such as comorbidities and coinfections, with the potential to transform understanding and treatment in this field.

Middle East Regional Cooperation (MERC): This grant program, managed by USAID, aims to fund collaborative research projects between Israeli and MENA region partners to address shared challenges, particularly in food security, and promote lasting peace through applied scientific research and technological development.

The "Reducing Barriers that Impede Access to Education and Decent Work for LGBTQI+ Youth in Brazil and the Latin American and Caribbean Region" grant is a $4 million funding opportunity from the U.S. Department of Labor to support a project that enhances understanding of, coordination for, and capacity to provide safe environments for LGBTQI+ youth, thereby improving their access to education and decent work in Brazil and the Latin American and Caribbean region.

With this solicitation, BJA seeks to support state, local, and tribal governments, as well as community-based nonprofit organizations, to establish, expand, or improve treatment and recovery support services for people with substance use disorders (SUDs) during their incarceration and upon reentry into the community. This program seeks to reduce crime and recidivism, expand access to evidence-based treatment, and promote long-term recovery for people leaving incarceration, and, in the process, improve public safety and public health.

This grant provides financial and technical support to a wide range of partners, including governments, nonprofits, and private entities, to remove barriers in waterways and restore aquatic habitats, benefiting local communities and ecosystems.

This funding opportunity supports researchers and organizations developing innovative tissue grafts to restore damaged brain tissue, targeting chronic neurological conditions affecting millions of people.

The purpose of this initiative is to advance research that reduces firearm injury and disparities through the development and evaluation of firearm injury primary prevention interventions leveraging community healthcare settings. This funding opportunity solicits applications that focus on primary prevention of firearm injury leveraging community healthcare settings. Applications may propose intervention studies with a rigorous design including, but not limited to, policy implementation studies, natural experiments and other studies with a quasi-experimental design, as well as those meeting the NIH definition of a clinical trial. Aims may focus on efficacy, effectiveness, or hybrid effectiveness/implementation research. Health or behavioral outcomes for this funding opportunity should be appropriate to the aims and should include, but are not limited to, changes in behavior related to firearm injury prevention and firearm safety procedures, and implementation outcomes. Change in knowledge of firearm injury prevention measures may be a secondary outcome (e.g., as a mechanism of action) but should not be the focus of the project. Multi-level, multi-disciplinary interventions and outcomes are encouraged, including individual, interpersonal, organizational, and community levels. Individual level outcomes should be one of the outcome levels included. Rigorous methods that address potential sources of bias that are appropriate to the study design are expected. Intervention studies are expected to include a theory-informed examination of the mechanisms of intervention effects. Projects that are responsive to this funding opportunity include R01 studies of all size, from small, single-site, three-year projects such as to adapt an intervention to the community or to test efficacy of an intervention, to large multi-site trials to test effectiveness and implementation strategies. Applications that meet any of the non-responsiveness criteria will be considered non-responsive and will not be reviewed. Implementation studies should include an evaluation of the effectiveness of the intervention in the site or sites. Years requested and project budgets should reflect the scope of the project. A description of plans for community engagement, including clear justification of the planned approach, is required. Projects that focus on populations that experience health disparities are highly encouraged.

This grant provides funding for innovative research to develop noninvasive techniques that improve sleep quality and cognitive performance for military personnel facing extreme sleep deprivation.

The FY24 RCRP Concept Award supports highly innovative, untested, potentially groundbreaking novel concepts in rare cancers. The Concept Award is not intended to support an incremental progression of an already established research project; instead, it allows Principal Investigators (PIs) the opportunity to pursue serendipitous observations. Preliminary data are not required. This award mechanism supports high-risk studies that have the potential to reveal entirely new avenues for investigation. Applications must describe how the new idea will enhance the existing knowledge of rare cancers or develop an innovative and novel course of investigation. Research completed through a Concept Award may generate sufficient preliminary data to enable the PI to prepare an application for future research.Reviewers will be blinded to the identity of the Principal Investigator (PI), collaborator(s), and their organization(s). Refer to Section II.D.2.b.i., Full Application Submission Type, for more information.A congressionally mandated Metastatic Cancer Task Force was formed with the purpose of identifying ways to help accelerate clinical and translational research aimed at extending the lives of advanced state and recurrent patients. As a member of the Metastatic Cancer Task Force, CDMRP encourages applicants to review the recommendations (https://health.mil/Reference-Center/Congressional-Testimonies/2018/05/03/Metastatic-Cancer-Research) and submit research ideas to address these recommendations provided they are within the limitations of this funding opportunity and fit within the FY24 RCRP prioritiesInnovative research involving nuclear medicine and related techniques to support early diagnosis, more effective treatment, and improved health outcomes of active-duty Service Members and their Families is encouraged. Such research could improve diagnostic and targeted treatment capabilities through noninvasive techniques and may drive the development of precision imaging and advanced targeted therapies.CDMRP encourages research on health areas and conditions that affect women uniquely, disproportionately, or differently from men, including studies analyzing sex as a biological variable. Such research should relate anticipated project findings to improvements in women's health outcomes and/or advancing knowledge for women's health.All projects should adhere to a core set of standards for rigorous study design and reporting to maximize the reproducibility and translational potential of clinical and preclinical research. The standards are described in SC Landis et al., 2012, A call for transparent reporting to optimize the predictive value of preclinical research, Nature 490:187-191 (https://www.nature.com/nature/journal/v490/n7419/full/nature11556.html). While these standards are written for preclinical studies, the basic principles of randomization, blinding, sample-size estimation, and data handling derive from well-established best practices in clinical studies.Applications from investigators within the military services and applications involving multidisciplinary collaborations among academia, industry, the military services, the U.S. Department of Veterans Affairs, and other federal government agencies are highly encouraged.DOD FY24 Rare Cancers Concept Award 5These relationships can leverage knowledge, infrastructure, and access to unique clinical populations that the collaborators bring to the research effort, ultimately advancing research that is of significance to Service Members, Veterans, and/or their Families. If the proposed research relies on access to unique resources or databases, the application must describe the access at the time of submission and include a plan for maintaining access as needed throughout the proposed research.Clinical trials are not allowed. A clinical trial is defined in the Code of Federal Regulations, Title 45, Part 46.102 (45 CFR 46.102) as a research study in which one or more human subjects are prospectively assigned to one or more interventions (which may include a placebo or another control) to evaluate the effects of the interventions on biomedical or behavioral health-related outcomes.Studies that do not seek to measure safety, effectiveness, and/or efficacy outcome(s) of an intervention are not considered clinical trials.

This funding opportunity supports state and local governments, port authorities, and private operators in developing marine transportation projects that provide efficient alternatives to congested land-based systems.

This grant invites innovative research proposals from a wide range of organizations to develop groundbreaking technologies in artificial intelligence, cybersecurity, and information systems that enhance U.S. national security.

This grant provides funding to nonprofit organizations that train instructors to educate hazardous materials employees on safe handling and transportation practices.

The "CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development" grant aims to fund the early-stage development of treatments to reduce the harmful health effects caused by exposure to toxic chemicals, which could be used in terrorist attacks or accidentally released from industrial sites, with the end goal of producing at least one well-characterized therapeutic candidate.

This funding opportunity is designed to support research centers in developing innovative vaccines against hepatitis C virus, targeting a wide range of applicants including universities, nonprofits, and government entities.

Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes.Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) invites applications for support of investigator-initiated studies addressing mechanisms by which bariatric surgery impacts cancer risk, and seeks to draw in talented scientists who study bariatric surgery to investigate its effects on cancer, rather than shorter-term outcomes such as weight loss and diabetes. Background Obesity: Obesity will soon surpass smoking tobacco as the number one cause of preventable death both in the United States and worldwide. Bariatric (metabolic) surgery is the most effective strategy to achieve significant initial and sustained weight loss among individuals who are morbidly obese. Bariatric surgery provides dramatic improvement in metabolic function, associated with a reduction in type 2 diabetes mellitus (T2DM) and cardiovascular (CV) risk. Bariatric surgery also appears to reduce the risk of certain obesity-related cancers, although which cancers are favorably impacted vary by study, and the mechanism(s) driving this risk reduction is mostly speculative. Bariatric surgery is performed in over 250,000 people in the U.S. annually, and the frequency is rising. Studies evaluating which bariatric surgery procedure(s) are most effective in cancer risk reduction could help bring to light new pathways to target for cancer prevention. Bariatric Surgery: Importantly, it is not yet clear from clinical and preclinical studies if the benefit from bariatric surgery arises from weight loss alone or if there is also a surgery-specific benefit. One mechanism for a possible surgery-specific effect is elevated bile acids (BA), both intestinal and circulating, after gastric bypass surgery such as Roux-en-Y gastric bypass (RYGB) that are proposed to be central to weight loss and other metabolic benefits. The interaction between BA and intestinal microbes is also an area of intense interest. Studies have identified important changes after bariatric surgery in the composition and function of the gut microbiome, which may mediate bariatric surgery effects. Fecal microbiota transplantation (FMT) from humans or mice that had undergone bariatric surgery to germ-free recipient mice showed decreased weight gain and decreased adiposity are both transmissible traits. In addition, FMT induced important host metabolic changes including decreased energy harvest from the diet, increased resting energy expenditure, and increased lipid utilization. The data suggest a causal link between gut microbiota and the metabolic and weight loss effects of bariatric surgery. If validated, the findings will provide insight into the mechanisms driving the benefit of bariatric surgery on cancer risk and would be useful to further scientific understanding and patient care. Animal Models: Several diets or genetically induced animal models of obesity have consistently demonstrated the benefits of weight loss on cancer risk, and these obesity-induced tumor models may be adaptable to bariatric surgery studies, such as the Kras model of pancreatic cancer. Animal models have been developed to study the effects of bariatric surgery. Rodent animal models are most often used due to feasibility (low cost, ease of housing) and have been used extensively to study the mechanism(s) of bariatric surgery responsible for the reduction or elimination of T2DM and CV risk. However, very little has been reported on bariatric surgery and cancer risk despite the fact that both rat and murine models of mammary and other cancers develop in 6 months or less, making it feasible to assess mechanistic changes that influence cancer risk. Bariatric Surgery and Cancer Risk: Obese patients undergo bariatric surgery for a variety of reasons, including weight loss and improvement in metabolic dysfunction. Physician advice regarding the potential benefit of bariatric surgery and cancer risk reduction can currently only be given in generalities based on large-scale studies and not targeted to the individual. Many but not all bariatric surgery investigations document an overall cancer risk reduction among women but not men. Some but not all bariatric surgery studies have found that both women and men undergoing bariatric surgery have an increased risk of colorectal cancer (CRC). Older studies which assessed bariatric surgery and cancer risk may not be useful to guide targeted advice to patients, as one of the most common procedures performed in the past, gastric banding, is only performed in 1% of bariatric surgery procedures today. The two most common bariatric surgery procedures currently performed are sleeve gastrectomy and RYGB. As such, planned animal and/or human studies should focus on the mechanistic effects of the two procedures that are currently in common use. Human biospecimens and/or data may be available from cohorts to enhance the studies proposed including the Longitudinal Assessment of Bariatric Surgery (LABS), Adolescent Bariatrics: Assessing Health Benefits & Risks (Teen-LABS), and NCI Cohort Consortium Members. Applications that include collaborators from fields outside of cancer research will be given special programmatic consideration. Responsive applications may investigate animal models, human studies, or a combination of both. General Area of Research and Scope of Work for this FOA General Area of Research Examples of relevant areas of research include but are not limited to: Do alterations in cancer risk biomarkers occur before weight loss? If so, in what organ, tissue, or cell type do they originate? Is maximum weight loss or long-term weight loss more important for cancer risk reduction? If so, how do the two differ at a cellular and/or biochemical level? What mechanism(s) explain the evidence that bariatric surgery is more beneficial in cancer risk reduction in women than men? Does bariatric surgery increase or decrease the risk of CRC, and if so, what are the mechanism(s)? Which cancers are decreased in incidence by bariatric surgery, and what are the mechanism(s) that explain the effect? Are any cancers increased in incidence by bariatric surgery? If so, through what mechanism(s)? Does the specific bariatric surgery procedure have an impact on cancer risk? If so, what are the mechanism(s) driving the difference in impact? Does racial or ethnic background influence the impact of bariatric surgery on cancer risk, and if so, what are the mechanism(s) involved? How does bariatric surgery affect the penetrance of high-risk genetic predisposition to cancer? Scope of Work and Additional Guidance It is anticipated that studies will evaluate bariatric surgery animal models where a significant proportion of the animals develop cancer. Similarly, human studies involving individuals who will or have undergone bariatric surgery are also encouraged, so long as within the cohort to be studied the number of enrolled subjects who develop cancer is adequate to for a statistically powered endpoint linking cancer (and not a biomarker of cancer) to a molecular mechanism as the driver of cancer. When appropriate and feasible, the investigators may want to evaluate mechanisms influenced by bariatric surgery in animal models of cancer and evaluate potential changes that might correlate with humans due to bariatric surgery. We define mechanism as a biologic endpoint based on analyzed samples from bariatric surgery animal models or from subjects who have or are planned to undergo bariatric surgery. This FOA does not support studies where an epidemiologic endpoint is the primary aim of the project. The mechanism(s) to be studied should evaluate samples collected from animals or humans who have undergone bariatric surgery who did or did not develop cancer. If both animals and humans are studied, the mechanisms chosen should be based on a cancer endpoint. Applications Not Responsive to This FOA The following types of activities remain outside the scope of this FOA, and applications proposing them are non-responsive to this FOA and will not be reviewed. This FOA is not intended for epidemiologic studies, where the primary endpoint is the assessment of cancer in a cohort of animals or humans, which has undergone bariatric surgery and mechanistic studies evaluating bodily fluid or tissue samples are nonexistent or of secondary endpoints. Application that focuses entirely on in vitro investigations. Epidemiologic investigations as the primary focus of the application. Animal or human studies that do not evaluate tissue and/or bodily fluid samples collected from participants who have undergone bariatric surgery, some of which developed cancer after surgery. Application, which includes a clinical trial that does not have a bariatric surgeon as a key investigator on the team. NOTE: Applicants to this FOA are strongly encouraged to contact NCI staff as soon as possible in the development of the application (preferably no later than 12 weeks prior to the application due date) to discuss the details of their proposed clinical trial, so that NCI staff can help the applicant understand whether the proposed clinical trial is within the goals and mission of the NCI and is appropriate for this FOA.

A. PROGRAM DESCRIPTION The U.S. Embassy Kyiv announces the 2024 Public Diplomacy Small Grants in Strategic Communications to support projects aimed at highlighting the importance of strategic communications and providing the tools to increase the outcome of the latter at the time of crisis, which would assist Ukraine to win the war and win the peace. Collaboration between the United States and Ukrainian organizations is encouraged. Priority Region: Ukraine Program Objectives: The U.S. Embassy Kyiv announces the 2024 Strategic Communications Grants Program (SCGP) to support projects aimed at strengthening capacities in strategic communications planning and delivery among, primarily, government officials and diplomats, as well as active think-tanks. Considering the ongoing war and anticipated challenges of the post-war period, effective communications become more important than ever. Establishing an effective dialogue with relevant audiences based on the principles of democracy and transparency requires a strategic approach to internal and external communications. The projects should be focused on exposing the target audiences to knowledge and developing the skills, necessary to clearly identify and communicate the priority goals, threats, and opportunities. Strategic Communications should be the focus of the projects, as a powerful tool for pursuing specific goals for Ukraine to win the war and win the future: Effectively use diplomatic tools to inform the world about security, humanitarian, and economic conditions, and bring in new international audiences and mechanisms to set the ground for a just and lasting peace. Unite Ukrainians by keeping strong ties with refugees outside Ukraine and reintegrating communities liberated from Russian occupation, internally displaced persons, returning refugees, victims of war-related violence, and veterans. Promote Ukraines strengthening its civil society and democratic and economic institutions and implementing anti-corruption and economic reforms and institutions to achieve sustainable momentum towards Euro-Atlantic integration to win a secure and just future that delivers prosperity for all its citizens. Participants and Audiences: All project activities supported by the U.S. Embassy grant should target Ukrainian professionals who have a strong communication component in their jobs. The target groups for the projects are Ukrainian institutions who have power to shape the official narrative which pragmatically addresses the war and post-war recovery period challenges, needs and plans so that they generate a positive perception in the Ukrainian society and in appropriate audiences abroad. The beneficiaries of the projects may include government officials of various levels (from territorial communities to the country management), diplomats, NGO leaders, media representatives, business leaders and other groups dealing with primary importance issues from military collaboration and war crimes investigation to Ukraine recovery, who need additional skills in planning and delivering messages to appropriate audiences. B. FEDERAL AWARD INFORMATION Length of performance period: six to twelve months Award amounts: awards may range from a minimum of 30 000 to a maximum of 85 000 USD Total available funding: pending funds availability Type of Funding: AEECA, Supplemental Funds Anticipated project start date: between July 1 and September 30, 2024 This notice is subject to availability of funding. Funding Instrument Type: Grant C. ELIGILIBITY INFORMATION 1. Eligible Applicants Ukrainian and U.S. not-for-profit organizations, including think tanks and civil society/non- governmental organizations (NGOs) and U.S. universities are eligible to apply. U.S. -Ukraine collaboration and partnerships are welcome. 2. Cost Sharing or Matching Cost sharing or matching is encouraged but not required. 3. Other Eligibility Requirements In order to be eligible to receive an award, all organizations must have a Unique Entity Identifier (UEI) number issued via www.SAM.gov as well as a valid registration on www.SAM.gov. Please see Section D.4 for more information. Individuals are not required to have a UEI or be registered in SAM.gov. Applicants are only allowed to submit one proposal per organization. If more than one proposal is submitted from an organization, all proposals from that institution will be considered ineligible for funding. Please see attached document for more application information.

The purpose of this project is to support Hondurans National Police (HNP) in the implementation of the Police Athletic League (PAL) program in Honduras. The targeted population is at-risk youth in Honduras between the ages of seven (7) and eighteen (18) who live in communities at high risk of violence and gang activity. The Police Athletic League will be launched by HNP Officers in November 2024 as a pilot program with approximately 2,500 children enrolled in 6 principal cities in Honduras: Tegucigalpa, San Pedro Sula, La Ceiba, Tela, La Paz and Roatan. Soccer will be one of the main target activities available nationwide, including leagues for both females and males for primary and middle school students. This initiative aims to promote inclusivity and equitable athletic development, with teams comprised of 18 participants each, including 6 female and 6 male players in primary and secondary schools.