Grants for State governments - Federal

The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. This program represents the continuation of a long-standing NIH program that provides support and "protected time" to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.

Notice of Funding Opportunity Description Background The accumulation of misprocessed and aberrant proteins is a defining characteristic of various neurodegenerative conditions, such as AD and frontotemporal lobar degeneration (FTLD). These atypical proteins may arise from various factors, such as somatic mutations, environmental changes, genomic instability, irregular RNA processing, and proteolytic cleavages, as well as incorrect folding and post-translational modifications. For instance, many recent proteome and transcriptome profiling of AD brains reveals RNA splicing dysfunction and abnormal accumulation of U1 small nuclear ribonucleoprotein (snRNP) and transactive response DNA-binding protein 43 (TDP-43). In AD, U1-70K and its N-terminal 40-KDa fragment (N40K) is one of the most abundant proteins in the insoluble fraction of cell lysates. TDP-43 is an RNA-binding protein. In AD, TDP-43 pathology is observed in approximately 25-50% of cases, particularly in cases with co-morbidities such as Lewy body dementia or hippocampal sclerosis. However, the relationship between U1snRNP/TDP-43 and AD pathology is complex and not fully understood. The disruption of RNA processing is thought to be one possible mechanism to cause the accumulation of misprocessed proteins, which can lead to altered expression of genes involved in AD pathology, including amyloid precursor protein (APP), tau, and synaptic proteins. Understanding the mechanisms underlying the dysregulation of misprocessed proteins in neurodegenerative diseases will be important for developing effective therapies. Approaches that target the production or aggregation of misprocessed proteins, or that promote their clearance or degradation, may be effective in preventing or slowing disease progression. Purpose This NOFO invites innovative research proposals to explore the accumulation of misprocessed proteins in Tauopathies within specific brain regions and cell types. This NOFO encourages collaborative efforts to create advanced single-cell or single-cell type proteogenomic platforms. These platforms aim to shed light on dynamic changes in protein-misfolding responses in neuronal proteomes and their potential biological consequences during aging and the development of AD/ADRD. Research Objectives This NOFO aims to provide a proof-of-principal for a novel strategy to identify misprocessed and aberrant proteins in Tau diseases using the proteogenomic approach. Proteogenomics is an integrated approach that combines proteomics and genomics data. In proteogenomics, genomic and transcriptomic experiments are more closely integrated to identify potential protein coding and non-coding regions in the genome. These regions are then validated using mass spectrometry-based proteomics. Proteogenomics has emerged as a powerful tool for investigating the role of protein homeostasis in AD pathogenesis, especially in the context of mis-translated and mis-repaired proteins. However, relying solely on misprocessed protein levels to draw conclusions about biological processes is unlikely to be reliable. Therefore, an intermediate layer of functional validation is essential to transform proteogeomic data into meaningful biological information. As a result, the objective of this NOFO is not only to confirm changes in protein abundance using other methods, but also to assess the biological effects of those changes in some model systems, especially in the area of tauopathies, to ensure high interlaboratory reproducibility. Using the proteogenomics approach, this NOFO aims to accomplish the following: Create a comprehensive database of misprocessed and aberrant proteins in selected mouse models of human Tau diseases. Cross-validate the presence of misprocessed and aberrant proteins in human AD/ADRD brains. Identify new molecular pathways and novel misprocessed protein-protein interaction networks that are not currently in most datasets. Define novel mechanisms through which misprocessed and aberrant proteins influence the onset and progression of neurodegeneration in tauopathies. Identify disease specific therapeutic targets in neurodegenerative diseases. It is expected that applications responding to this initiative will use the latest cell-type-specific labeling and proteogenomic techniques with suitable model systems to understand the etiology of tauopathies in aging and AD.

The Public Diplomacy Section of the U.S. Embassy in Madrid and U.S. Consulate General in Barcelona (known collectively as PD Spain) of the U.S. Department of State announces an open competition for organizations to submit proposals to design, manage, and implement Defensa y Yo 5.0, a program promoting security and defense issues among Spanish and Andorran public university students. In 2021, working with a local partner organization, Mission Spain established "Defensa y Yo" (DyY) a program promoting security and defense issues among Spanish youth. The program includes three elements: 1) Lectures by U.S. experts in select Spanish public universities on a variety of topics related to security and defense. 2) Attendees can then participate in a competition where they submit a project on one of the topics covered in the lecture series. 3) A winner is selected from each university, with winning students traveling to Brussels to visit NATO headquarters and other security and defense institutions. For this fifth edition of the Defensa y Yo program, Mission Spain welcomes creative proposals to continue the program in sixteen selected Spanish public universities, strengthen the relationships with both the university administrators and professors, and engage the network of participants from the four previous editions. Program Objectives: Objective 1: Spanish public university students gain knowledge and tools to discuss and share accurate information on security and defense issues with their peers and become better informed future leaders. Objective 2: Strong relationships are formed with both the university administrators and professors. Objective 3: Mentorship relationships are formed between participating students of all four editions of DyY and the alumni association GEOSEDE. Recipient Responsibilities: This award will be separated into two parts to include a non-competitive continuation clause based on awardee performance and execution of the program objectives detailed below in part one. Funding for part two of the project is not guaranteed, and the renewal of the award to cover the second part of the project is at the discretion of the Department of State, and will be evaluated based on successful completion of the recipient responsibilities and program objectives. Part One: 1. Develop and implement a program consisting of a series of lectures (in-person or virtual, when necessary) on security and defense themes featuring a U.S. expert (i.e. representatives from academia, civil society, international organizations, think tanks, U.S. government, etc.). These lectures will take place at sixteen selected Spanish public universities - one session per university from February 2025 to May 2025. Ideally, the grantee will invite a total of four speakers, one per month. Each speaker would reach four of the participating universities during the course of one week. These U.S. speakers will be selected by the grantee in collaboration with PD Spain. 2. Prepare program guidelines and other relevant materials for professors of the participating Defensa y Yo universities. 3. Conduct a formal registration of all attendees of the Defensa y Yo sessions at the sixteen participating universities. Design and conduct qualitative and quantitative research pre and post program via survey, focus groups, etc. to measure the programs effect on the participants as well as general trends, mindsets, and knowledge of the target audience on security and defense issues. 4. Maintain and support the existing Defensa y Yo website to convey program information and highlights with featured editorial space on the grantee’s website. 5. Develop and implement a media and social media plan, with a specific emphasis on promoting the program and highlighting program impact in the sixteen universities. The press and social media campaign should be coordinated with the communications departments of the participating universities and PD Spain. 6. Develop a competition for lecture attendees (students) that identifies the best project per University around a chosen theme related to security and defense issues. Pieces should be submitted by the student participants of the Defensa y Yo program who have registered and attended the Defensa y Yo sessions; 7. Develop a transparent review process that involves PD Spain to evaluate competition applicants (one selected candidate from each one of the participating universities) for the exchange program in Brussels. 8. Organize a professional development opportunity for all 16 professors from participating universities to strengthen their network and knowledge in defense-related topics. Coordinate travel logistics, provide necessary documentation, and implement engaging activities. Part Two: 9. Conduct a pre-departure orientation (in-person, in Madrid) for Defensa y Yo Fellows before their departures from the city where their university is located to Madrid and Brussels; 10. Create program materials (both electronic and print) to assist finalists in preparing for their fellowship in Brussels, and answer questions on programmatic issues, including, but not limited to, program responsibilities and expectations, travel, accident and sickness benefits, lodging and meals and incidentals, leadership development, etc.; 11. Arrange and cover via award the cost of all appropriate program-related travel for Defensa y Yo Fellows to participate in a 4-day exchange program in Madrid and Brussels in the fall of 2025, including but not limited to transportation, lodging, and meals and incidental expenses, etc.; 12. Develop and implement a social media plan during the exchange program in Brussels, with a specific emphasis on the student winners participating in the program; 13. Manage financial aspects of the program including timely disbursement of participant meal and incidental stipends, lodging and travel allowances, etc. and promptly report any irregularities in the budget or spending to PD Spain both for participating speakers, participating professors, and selected student winners during their exchange program; 14. Participate in regular program reviews and meetings with PD Spain (in person or by telephone) that provide general updates on program implementation and matters of concern including but not limited to a review of the effectiveness of past activities, progress on anticipated programmatic activities, and issues that may impede the implementation of planned programming; 15. Respond fully and promptly to requests for program or statistical information from PD Spain, including but not limited to providing information through spreadsheets and databases; 16. Ensure compliance with the terms of this NOFO, including but not limited to submitting timely financial and program reports and proper budget oversight. Participants and Audiences: Project should involve at least 500 Spanish public university undergraduate students (18-25) enrolled in International Relations, Law, Journalism, and Business Administration programs at sixteen universities, and a network of professors of all sixteen selected universities. Further Information: Further information and application instructions can be found on the U.S. Embassy Consulate in Spain and Andorra website: https://es.usembassy.gov/grants-programs/ as well as an attachment on this posting. Any questions about the opportunity or the application should be directed to [email protected]. NOTE: This notice is subject to availability of funding.

This grant provides funding to organizations for conducting essential studies and analyses to improve the water intake system at a fish hatchery in California, ensuring the sustainability of fish populations and the recovery of endangered salmon species.

This funding opportunity provides financial support to healthcare systems and organizations to implement a comprehensive suicide prevention model aimed at improving mental health outcomes and reducing suicide rates.

This funding opportunity supports researchers exploring the mechanisms of Treponema pallidum, the bacteria responsible for syphilis, to address the rising rates of sexually transmitted infections and improve understanding of its pathogenesis.

This funding opportunity provides financial support to individuals, businesses, and organizations working to improve U.S. fisheries through marketing, infrastructure development, and innovative science or technology initiatives.

This grant provides funding for research projects that test strategies to reduce suicide risk by promoting safe storage of lethal means, such as firearms, in healthcare and community settings.

The "Spotlight on Humanities in Higher Education" grant provides funding to enhance humanities education for underserved student populations at small colleges and universities, supporting projects that improve teaching and learning outcomes in the humanities.

This funding opportunity supports innovative research projects that utilize genomic data from a specific cloud-based platform to answer important biological questions and improve data accessibility for the scientific community.

With this solicitation, OJJDP seeks to provide support to CACs through a variety of subgrant assistance designed to enhance effective interventions in child abuse cases. CACs provide a coordinated response to child abuse victims through multidisciplinary teams composed of representatives from the agencies involved in the intervention, prevention, prosecution, and investigation systems that respond to child abuse.

The "Innovation Grants to Nurture Initial Translational Efforts (IGNITE)" program supports the development of in vitro and ex vivo assays to identify and characterize new therapeutic agents for neurological and neuromuscular disorders, with a focus on creating robust screening methods for promising neurotherapeutics.

This funding opportunity supports exploratory preclinical studies to evaluate the effectiveness of therapeutic agents for rare diseases affecting fewer than 200,000 people in the U.S., aiming to advance these treatments toward clinical trials.

The "NIDCD's Mentoring Networks to Enhance Clinician-Scientists' Participation in Research" grant aims to support educational and mentoring activities that encourage individuals, especially those from diverse backgrounds, to pursue research careers in biomedical, behavioral, and clinical sciences, with a particular focus on improving the recruitment, preparation, and retention of clinician investigators.

This grant provides funding for advanced graduate students to conduct dissertation research in collaboration with Head Start programs, focusing on early childhood education for low-income families.

This grant provides funding to early-career researchers in mental health to support innovative projects that advance the understanding and treatment of mental illnesses.

This program will constitute a national CBA Provider Network (CPN) to deliver CBA services to an interdisciplinary HIV prevention workforce (e.g., professional, technical, clinical, and managerial staff) within CDC-funded state and local health departments and CBOs. In the United States, an estimated 1.2 million people are living with HIV. In recent years, the number of people with HIV (PWH) has increased while deaths have declined. Of PWH, about 87% were aware of their HIV status. In 2021, among people with diagnosed HIV, an estimated 75% received HIV medical care and 66% were virally suppressed. Promising progress has been made in HIV prevention as the estimated annual new HIV infections were 12% lower in 2021 (32,100 infections) compared to 2017 (36,500 infections). This decline was largely driven by a substantial decrease (34%) in new infections among 13- to 24-year-olds, mostly among gay and bisexual males. However, HIV prevention efforts must go further, and progress must be faster, for gains to equitably reach all populations and end the HIV epidemic. The National HIV/AIDS Strategy (NHAS) for the United States focuses on four goals: preventing new HIV infections, improving HIV-related health outcomes of people with HIV, reducing HIV-related disparities and health inequities, and achieving integrated, coordinated efforts that address the HIV epidemic among all partners. Successful HIV programs must recognize the syndemics that affect the people and places disproportionately affected by HIV. A syndemic is population-level clustering of social and health problems. In the context of HIV, a syndemic is when HIV clusters with one or more other diseases or health conditions within a specific population, driven by the contextual, structural and social factors that increase the adverse effects on the health of people and communities. Syndemics may include HIV, STIs, TB, viral hepatitis, overdose, and substance use, and other existing and emerging conditions or factors that may be related to or impact HIV. The Ending the HIV Epidemic in the US (EHE) initiative focuses on scaling up four sciencebased strategies in communities most affected by HIV across the country. The strategies are to diagnose all people with HIV as early as possible; treat people with HIV rapidly and effectively to result in sustained viral suppression; prevent new HIV transmissions by using proven interventions, including condom distribution, pre-exposure prophylaxis (PrEP), postexposure prophylaxis (PEP), and syringe services programs (SSP); and respond quickly to potential HIV outbreaks to get vital prevention and treatment services to people who need them. Toward achieving national HIV prevention goals, the Centers for Disease Control and Prevention (CDC) funds state and local health departments and community-based organizations (CBOs) to plan, integrate, implement, evaluate, and sustain HIV prevention and surveillance programs, prioritizing people disproportionately affected by HIV including gay, bisexual, and other men who have sex with men, in particular Black, Latino, and American Indian/Alaska Native men, Black women, transgender women, youth aged 13-24, and people who inject drugs. Racism, HIV stigma, discrimination, homophobia, poverty, and barriers to health care continue to drive disparities in HIV prevention. Building individual competencies and technical expertise among staff, strengthening organizational capacities, and enabling supportive structural environments are critical strategies Page 5 of 81 in addressing operational challenges for more effective HIV prevention and surveillance programs. Reflecting CDC’s continued investment in improving the performance of the nation’s HIV workforce, this NOFO will support the provision of capacity building assistance (CBA) services, including training and technical assistance (TA).

This funding opportunity provides financial support for U.S. institutions and organizations to develop innovative methods for identifying and safely sealing undocumented orphaned oil and gas wells, thereby reducing methane emissions and environmental risks.

This funding opportunity supports innovative clinical trials aimed at improving health and quality of life for individuals with Down syndrome, inviting a wide range of organizations to apply for financial assistance in addressing critical health issues associated with the condition.

Under this Funding Opportunity Announcement (FOA), DOL will award grants through a competitive process to organizations providing pre-apprenticeship services that support education, occupational skills training, and employment services to opportunity youth, ages 16 to 24, who are performing meaningful work and service to their communities. The YouthBuild program model prepares participants for quality jobs in a variety of careers, in diverse industry sectors, particularly in infrastructure sectors, and includes wrap-around services such as mentoring, trauma-informed care, personal counseling, transportation supports, and employment preparation - all key strategies for addressing violence in communities. YouthBuild applicants must include construction skills training and may include occupational skills training in other in-demand industries. This expansion into additional in-demand industries is the Construction Plus component. Eligible applicants for these grants are public or private non-profit agencies or organizations, including consortia of such agencies or organizations. These organizations include rural, urban, or Native American/Tribal entities that have previously served opportunity youth in a YouthBuild or other similar program. DOL will fund approximately 75 projects across the country. Individual grants will range from $700,000 to $1.5 million and require a 25 percent match from applicants, using sources other than federal funding. This FOA features a matching waiver for Tribal entities and U.S. insular areas which allows these entities to not include a match commitment in their applications. The grant period of performance for this FOA is 40 months, including a four-month planning period and a twelve-month follow-up period.